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1

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

Kleinstreuer, Nicole C, Yang, Jian, Berg, Ellen L, Knudsen, Thomas B, Richard, Ann M, Martin, Matthew T, Reif, David M, Judson, Richard S, Polokoff, Mark, Dix, David J, Kavlock, Robert J, Houck, Keith

Journal:

Nature Biotechnology

Year:

2014

Language:

english

File:

PDF, 1.72 MB

english, 2014

2

8.6.3 Systems Thinking Applied to Teaming

Hoheb, Albert C., Polokoff, Elyse, Tilney, Lindsay

Journal:

INCOSE International Symposium

Year:

2001

Language:

english

File:

PDF, 539 KB

english, 2001

3

High capacity screening of pooled compounds: Identification of the active compound without re-assay of pool members

James J. Devlin, Amy Liang, Lan Trinh, Mark A. Polokoff, David Senator, Wei Zheng, Jason Kondracki, Peter J. Kretschmer, John Morser, Samuel E. Lipson, Richard Spann, John A. Loughlin, Kathryn V. Dunn

Journal:

Drug Development Research

Year:

1996

Language:

english

File:

PDF, 560 KB

english, 1996

4

Effect of chronic ethanol administration on enzyme and lipid properties of liver plasma membranes in long and short sleep mice

Thomas Zysset, Mark A. Polokoff, Francis R. Simon

Journal:

Year:

1985

Language:

english

File:

PDF, 754 KB

english, 1985

5

Characterization of HMG CoA synthase activity of rat liver and CHO-K1 cells

Robin Schnitzer-Polokoff, Michael Sinensky

Journal:

Journal of Cellular Biochemistry

Year:

1987

Language:

english

File:

PDF, 666 KB

english, 1987

6

The rational design of inhibitors of nitric oxide formation by inducible nitric oxide synthase

Marc Whitlow, Marc Adler, David Davey, Qinglan Huang, Sunil Koovakkat, John F. Parkinson, Eric Pham, Mark Polokoff, Wei Xu, Shendong Yuan, Gary Phillips

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 315 KB

english, 2007

7

1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation

Robert G. Wei, Marc Adler, David Davey, Elena Ho, Raju Mohan, Mark Polokoff, Jih-Lie Tseng, Marc Whitlow, Wei Xu, Shendong Yuan, Gary Phillips

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 974 KB

english, 2007

8

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity

Imadul Islam, Judi Bryant, Yuo-Ling Chou, Monica J. Kochanny, Wheeseong Lee, Gary B. Phillips, Hongyi Yu, Marc Adler, Marc Whitlow, Elena Ho, Dao Lentz, Mark A. Polokoff, Babu Subramanyam, James M. Wu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 416 KB

english, 2007

9

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX-517

Imadul Islam, Greg Brown, Judi Bryant, Paul Hrvatin, Monica J. Kochanny, Gary B. Phillips, Shendong Yuan, Marc Adler, Marc Whitlow, Dao Lentz, Mark A. Polokoff, James Wu, Jun Shen, Janette Walters, El

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 405 KB

english, 2007

10

Regulated production of recombinant echistatin by yeast

C. E. Carty, K. J. Hofmann, P. M. Keller, M. A. Polokoff, R. J. Lynch, B. J. Keech, R. J. Gould, R. Z. Maigetter, L. D. Schultz

Journal:

Biotechnology Letters

Year:

1990

Language:

english

File:

PDF, 360 KB

english, 1990

11

Breast Pain and Rash in an End-Stage Renal Disease Patient Following Coronary Artery Bypass Grafting

Gang Li, Ellen G. Polokoff, Lucian Panait, David Roer

Journal:

Seminars in Dialysis

Year:

2007

Language:

english

File:

PDF, 492 KB

english, 2007

12

Analysis of the coordinate expression of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities in Chinese hamster ovary fibroblasts

Robin Schnitzer-Polokoff, Robert Torget, Judy Logel, Michael Sinensky

Journal:

Archives of Biochemistry and Biophysics

Year:

1983

Language:

english

File:

PDF, 1.84 MB

english, 1983

13

Yeast thioltransferase—The active site cysteines display differential reactivity

Zhong-Ru Gan, Mohinder K. Sardana, John W. Jacobs, Mark A Polokoff

Journal:

Archives of Biochemistry and Biophysics

Year:

1990

Language:

english

File:

PDF, 836 KB

english, 1990

14

Solubilization, partial purification and characterization of rat liver microsomal diacylglycerol acyltransferase

Mark A. Polokoff, Robert M. Bell

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1980

Language:

english

File:

PDF, 1.21 MB

english, 1980

15

Complete amino acid sequence of yeast thioltransferase (glutaredoxin)

Zhong-Ru Gan, Mark A. Polokoff, John W. Jacobs, Mohinder K. Sardana

Journal:

Biochemical and Biophysical Research Communications

Year:

1990

Language:

english

File:

PDF, 426 KB

english, 1990

16

A somatic cell mutant with a kinetically altered 3-hydroxy-3-methylglutaryl coenzyme A reductase

Michael Sinensky, Judy Logel, Robin Schnitzer-Polokoff, Rae Ann Norcross

Journal:

Year:

1985

Language:

english

File:

PDF, 419 KB

english, 1985

17

The effect of mevinolin on cytosolic acetoacetyl coenzyme a thiolase activity in Chinese hamster ovary fibroblasts

Robin Schnitzer-Polokoff

Journal:

Biochemical and Biophysical Research Communications

Year:

1986

Language:

english

File:

PDF, 324 KB

english, 1986

18

Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461

Brian G Salisbury, Harry R Davis, Robert E Burrier, Duane A Burnett, George Boykow, Mary Ann Caplen, Anthony L Clemmons, Douglas S Compton, Lizbeth M Hoos, Daniel G McGregor, Robin Schnitzer-Polokoff,

Journal:

Atherosclerosis

Year:

1995

Language:

english

File:

PDF, 1.58 MB

english, 1995

19

249 Novel small molecule inhibitors of 3′-phosphoinositide-dependent kinase-1 (PDK-1)

R.I. Feldman, J.M. Wu, M. Polokoff, D. Zhu, S. Biroc, B. Alicke, S. Yuan, B. Buckman, Z. Chang, D. Arnaiz

Journal:

European Journal of Cancer Supplements

Year:

2004

Language:

english

File:

PDF, 140 KB

english, 2004

20

Hypertriacylglycerolemia in the chick: Effect of estrogen on hepatic microsomal enzymes of triacylglycerol and phospholipid synthesis

Rosalind Coleman, Mark A. Polokoff, Robert M. Bell

Journal:

Year:

1977

Language:

english

File:

PDF, 621 KB

english, 1977

21

The effect of acarbose on the food intake, weight gain, and adiposity of LA/N-cp rats

Vedula, Usha, Schnitzer-Polokoff, Robin, Tulp, Orien L.

Journal:

Comparative Biochemistry and Physiology Part A: Physiology

Year:

1991

Language:

english

File:

PDF, 778 KB

english, 1991

22

Effects of acyl-CoA: Cholesterol O-acyltransferase inhibition on cholesterol absorption and plasma lipoprotein composition in hamsters

Schnitzer-Polokoff, Robin, Compton, Doug, Boykow, George, vis, Harry Da, Burrier, Robert

Journal:

Comparative Biochemistry and Physiology Part A: Physiology

Year:

1991

Language:

english

File:

PDF, 734 KB

english, 1991

23

High-level expression in Escherichia coli of a chemically synthesized gene for [Leu-28]echistatin

Can, Zhong-Ru, Condra, Jon H., Gould, Robert J., Zivin, Robert A., Bennett, Carl D., Jacobs, John W., Friedman, Paul A., Polokoff, Mark A.

Journal:

Year:

1989

Language:

english

File:

PDF, 776 KB

english, 1989

24

Gender differences in vascular reactivity in hamsters fed a cholesterol diet

Kauser, K., Sonnenberg, D., Henrichmann, F., Werner, M., Whitcomb, J., Wilson, K., Polokoff, R., Vergona, R., Rubanyi, G.M.

Journal:

Atherosclerosis

Year:

1994

Language:

english

File:

PDF, 160 KB

english, 1994

25

The effects of the intestinal glucosidase inhibitor acarbose on cholesterogenesis in corpulent rats

Tulp, Orien L, Abdollahi, Abbas, Stevens, Carol, Schnitzer-Polokoff, Robin

Journal:

Comparative Biochemistry and Physiology Part A: Physiology

Year:

1991

Language:

english

File:

PDF, 680 KB

english, 1991

26

S50. Proffered paper: Complex tumour microenvironment screening platform captures biological responses of cancer therapeutics

Layman, H, Melrose, J, Tang, W, Brown, N, Nguyen, D, Melton, A, Polokoff, M, Berg, E, O'Mahony, A

Journal:

Journal for ImmunoTherapy of Cancer

Year:

2014

Language:

english

File:

PDF, 71 KB

english, 2014

27

Chronic ethanol increases liver plasma membrane fluidity

Polokoff, Mark A., Simon, Thomas J., Harris, R. Adron, Simin, Francis R., Iwahashi, Mieko

Journal:

Year:

1985

Language:

english

File:

PDF, 835 KB

english, 1985

28

Hydroxamic Acids as Potent Inhibitors of Endothelin-Converting Enzyme from Human Bronchiolar Smooth Muscle

Bihovsky, Ron, Levinson, Barry L., Loewi, Rivka C., Erhardt, Paul W., Polokoff, Mark A.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.50 MB

english, 1995

29

Elucidating adverse outcome pathways with phenotypic data from primary human cell systems

Berg, Ellen, Polokoff, Mark, O’Mahony, Alison, Yang, Jian

Journal:

Toxicology Letters

Year:

2014

Language:

english

File:

PDF, 76 KB

english, 2014

30

Mechanistic Studies with Potent and Selective Inducible Nitric-oxide Synthase Dimerization Inhibitors

Blasko, E., Glaser, C. B., Devlin, J. J., Xia, W., Feldman, R. I., Polokoff, M. A., Phillips, G. B., Whitlow, M., Auld, D. S., McMillan, K., Ghosh, S., Stuehr, D. J., Parkinson, J. F.

Journal:

Journal of Biological Chemistry

Year:

2002

Language:

english

File:

PDF, 680 KB

english, 2002

31

Building Predictive Models for Mechanism-of-Action Classification from Phenotypic Assay Data Sets

Berg, E. L., Yang, J., Polokoff, M. A.

Journal:

Journal of Biomolecular Screening

Year:

2013

Language:

english

File:

PDF, 631 KB

english, 2013

32

Effects of Phenotype, Sex, and Diet on Plasma Lipids in LA/N-cp Rats

Schnitzer-Polokoff, R., Margetin, C., Abdollahi, A., Tulp, O.

Journal:

Experimental Biology and Medicine

Year:

1989

Language:

english

File:

PDF, 575 KB

english, 1989

33

Disintegrins: A Family of Integrin Inhibitory Proteins from Viper Venoms

Gould, R. J., Polokoff, M. A., Friedman, P. A., Huang, T.-F., Holt, J. C., Cook, J. J., Niewiarowski, S.

Journal:

Experimental Biology and Medicine

Year:

1990

Language:

english

File:

PDF, 480 KB

english, 1990

34

Antibodies Neutralizing Hepsin Protease Activity Do Not Impact Cell Growth but Inhibit Invasion of Prostate and Ovarian Tumor Cells in Culture

Xuan, J.-A., Schneider, D., Toy, P., Lin, R., Newton, A., Zhu, Y., Finster, S., Vogel, D., Mintzer, B., Dinter, H., Light, D., Parry, R., Polokoff, M., Whitlow, M., Wu, Q., Parry, G.

Journal:

Cancer Research

Year:

2006

Language:

english

File:

PDF, 638 KB

english, 2006

35

A Statewide Consortium's Adoption of a Unified Nursing Curriculum: Evaluation of the First Two Years

Tse, Alice M., Niederhauser, Victoria, Steffen, John J., Magnussen, Lois, Morrisette, Nova, Polokoff, Rachael, Chock, Johnelle

Journal:

Nursing Education Perspectives

Year:

2014

Language:

english

File:

PDF, 454 KB

english, 2014

36

Acceleration of recombinant tissue-type plasminogen activator-induced thrombolysis and prevention of reocclusion by the combination of heparin and the Arg-Gly-Asp-containing peptide bitistatin in a canine model of coronary thrombosis

Shebuski, R. J., Stabilito, I. J., Sitko, G. R., Polokoff, M. H.

Journal:

Year:

1990

Language:

english

File:

PDF, 2.05 MB

english, 1990

37

Elucidating Mechanisms of Toxicity Using Phenotypic Data from Primary Human Cell Systems—A Chemical Biology Approach for Thrombosis-Related Side Effects

Berg, Ellen, Polokoff, Mark, O'Mahony, Alison, Nguyen, Dat, Li, Xitong

Journal:

International Journal of Molecular Sciences

Year:

2015

Language:

english

File:

PDF, 865 KB

english, 2015

38

Characterization of Novel PI3KÎ´ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies

Haselmayer, Philipp, Camps, Montserrat, Muzerelle, Mathilde, El Bawab, Samer, Waltzinger, Caroline, Bruns, Lisa, Abla, Nada, Polokoff, Mark A., Jond-Necand, Carole, Gaudet, MarilÃ¨ne, Benoit, Audrey,

Journal:

Frontiers in Immunology

Year:

2014

Language:

english

File:

PDF, 3.58 MB

english, 2014

39

Evidence of Glycosylated Sites on the Endothelin-1 Receptor in Swiss 3T3 Cells

Devesly, Pierre, Cade, Christina, Polokoff, Mark A., Parker Botelho, Lynne H.

Journal:

Journal of Cardiovascular Pharmacology

Year:

1991

File:

PDF, 259 KB

1991

40

Changes of Endothelial Nitric Oxide Synthase Level and Activity During Endothelial Cell Proliferation

Zöllner, S., Aberle, S., Harvey, S. E., Polokoff, M. A., Rubanyi, G. M.

Journal:

Year:

2000

Language:

english

File:

PDF, 1.29 MB

english, 2000

41

Sodium bicarbonate administration affects the diagnostic accuracy of gastrointestinal tonometry in acute mesenteric ischemia

BENJAMIN, ERNEST, POLOKOFF, ELLEN, OROPELLO, JOHN M., LEIBOWITZ, ANDREW B., IBERTI, THOMAS J.

Journal:

Critical Care Medicine

Year:

1992

File:

PDF, 293 KB

1992

42

RAPAMYCIN, CYCLOSPORINE, AND PERIOPERATIVE DONOR-SPECIFIC TRANSFUSIONS INDUCE PROLONGATION OF CARDIAC ALLOGRAFT SURVIVAL IN THE RAT

Knight, Richard J., Polokoff, Ellen G., Martinelli, Giorgio P.

Journal:

Transplantation Journal

Year:

1994

File:

PDF, 756 KB

1994

43

OP0282 Mavrilimumab Reduces IL-17A and IL-17F Production in Biomap Human Primary Cell Systems Modeling T Cell-Dependent B Cell Activation

Sleeman, M., O'Mahony, A., Polokoff, M., Scott, I.

Journal:

Annals of the Rheumatic Diseases

Year:

2014

Language:

english

File:

PDF, 88 KB

english, 2014

44

Regulation of IL-17A Production Is Distinct from IL-17F in a Primary Human Cell Co-culture Model of T Cell-Mediated B Cell Activation

Melton, Andrew C., Melrose, Jennifer, Alajoki, Liisa, Privat, Sylvie, Cho, Hannah, Brown, Naomi, Plavec, Ana Marija, Nguyen, Dat, Johnston, Elijah D., Yang, Jian, Polokoff, Mark A., Plavec, Ivan, Berg

Journal:

Year:

2013

Language:

english

File:

PDF, 3.07 MB

english, 2013

45

Effect of Fluoride on the Absorption of Dietary Fat in Rats

Schnitzer-Polokoff, Robin, Suttie, John W.

Journal:

Journal of Nutrition

Year:

1981

Language:

english

File:

PDF, 961 KB

english, 1981

46

Toxicity of Palmitoyl Glycerol to Mice: Hypothermia and Reversal of the Toxicity

Siddhanti, Suresh R., Trumbo, Paula R., Schnitzer-Polokoff, Robin, King, Margaret W., Tove, Samuel B.

Journal:

Journal of Nutrition

Year:

1987

Language:

english

File:

PDF, 543 KB

english, 1987

47

Interstital Pneumonitis Induced by Ingestion of Palmitoyl Glycerol

Schnitzer-Polokoff, Robin, Kanich, Robert E., Tove, Samuel B.

Journal:

Journal of Nutrition

Year:

1980

Language:

english

File:

PDF, 1.74 MB

english, 1980